Daclatasvir Dihydrochloride
Tuairisgeul
Tha Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) cumhachdach agus beòil gnìomhachHCV NS5A pròtaininhibitor leEC50s raon de 9-146 pm airsoniomadh genotypes mac-samhail HCV.Tha Daclatasvir dihydrochloride cuideachd aanion organach a 'giùlan polypeptide 1B (OATP1B)agusOATP1B3inhibitor leIC50s de 1.5 µM agus 3.27 µM, fa leth.
IC50& Targaid
EC50: 50 pM (genotype mac-samhail HCV 1a), 9 pM (genotype mac-samhail HCV 1b), 71 pM (genotype mac-samhail HCV 2a), 146 pM (genotype mac-samhail HCV 3a), 12 pM (genotype mac-samhail HCV 3a) agus 3a Genotype mac-samhail HCV 5a)[1]
Kd: 8 nM (NS5A33-202) agus 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) agus 3.27 µM (OATP1B3)[3]
Ann an Vitro
Tha Daclatasvir (BMS-790052) a’ nochdadh gnìomhachd bacaidh làidir a dh’ ionnsaigh a h-uile genotypes a chaidh a dhearbhadh, le EC50luachan eadar 9f agus 146f.Tha Daclatasvir a’ cur bacadh air mac-samhail HCV genotype 1a, 1b, 2a, 3a, 4a agus 5a le EC50luachan de 50 pM, 9 pM, 71 pM, 146 pM, 12 pM agus 33 pM, fa leth.Tha Daclatasvir na neach-dìon làidir den bhìoras gabhaltach genotype 2a JFH-1 a tha ag ath-riochdachadh ann an cultar cealla (EC50=28f)[1].Bidh Daclatasvir (BMS-790052) a’ ceangal gu teann ri NS5A33-202 agus NS5A26-202 le Kds de 8 nM agus 210 nM, fa leth[2].
Stòradh
| Pùdar | -20°C | 3 bliadhna |
| 4°C | 2 bhliadhna | |
| Ann an solus | -80°C | 6 mìosan |
| -20°C | 1 mìos |
Deuchainn clionaigeach
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Moladh18Pròiseactan Measadh Co-sheasmhachd Càileachd a tha air aontachadh4, agus6tha pròiseactan fo cheadachas.
Tha siostam riaghlaidh càileachd adhartach eadar-nàiseanta air bunait làidir a chuir sìos airson reic.
Bidh stiùireadh càileachd a’ ruith tro chuairt-beatha iomlan an toraidh gus dèanamh cinnteach à càileachd agus buaidh therapach.
Bidh sgioba Cùisean Riaghlaidh Proifeasanta a’ toirt taic do na h-iarrtasan càileachd rè an tagraidh agus a’ chlàraidh.
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